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Ortho Phthalaldehyde Instrument Disinfectant Solution from China Factory

SNOW-Brand 0.55% Ortho Pthalaldehyde Solution is a ready-to-use solution formulated with pharmacopoeia water.
 
OPA based disinfectant is a high level disinfectant for reprocessing thermostable and thermolabile devices. Please use it after reading the Directions for Use. Medical devices must be thoroughly cleaned before reprocessing in the disinfectant,thoroughly rinse and rough dry all surface and lumens of cleaned devices before immersing in OPA solution.
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SNOW-Brand 0.55% Ortho Pthalaldehyde Solution is a ready-to-use solution formulated with pharmacopoeia water.


OPA based disinfectant is a high level disinfectant for reprocessing thermostable and thermolabile devices. Please use it after reading the Directions for Use. Medical devices must be thoroughly cleaned before reprocessing in the disinfectant,thoroughly rinse and rough dry all surface and lumens of cleaned devices before immersing in OPA solution.

FEATURES & BENEFITS :
1. SNOW-brand 0.55% OPA solution  is a wide range of endoscopes and other heat-sensitive semi-critical medical devices Ideal for both automated and manual instrument reprocessing.
2. Faster turnaround time disinfectant with 5 minute contact time.
3. Long shelf-life up to 24 month
4. Test strip is escorted, easy to monitor the concentration.

5. No activation, ready to use

6. Irritant to the eyes and nasal passages

7. Excellent stability over a wide range of pH

8. Does not require exposure monitoring

9. Barely perceptible odor


OPA ortho-Phthalaldehyde Solution is a High-level Disinfectant for semi-critical medical devices and instruments.
Active Ingredient:  0.55% ortho-Phthalaldehyde .


opa application 5L

Endoscope and other hospital device sterilization.



Directions

How to Use ortho phthalaldehyde disinfectant OPA to Disinfect Medical Equipment?


· Wear Protective Clothes and gloves

· Clean the medical Device

· Check the OPA Solution concentration

· Disinfection Procedure

· Rinsing the Instruments

· Drying the Instruments

· Disposal of used OPA Solution


· Read the directions on the label before use.

·  OPA is a ready to use solution, no need to be activated . Simply open the bottle and pour it  into the containers.

·  Keep away from children.

· Avoid exposure to skin. Wear protective clothing, gloves, full suit, boots.

· Do not use to disinfectant needle, surgical suture. Do not mix with other toxic .

1.Q: How can you control your quality?
A: We inspect the goods during production and supervise after the production. Our senior engineers test the products randomly.


2.Q:What is your payment term?
A: Less than 10000 USD, T/T in advance. Over 10000 USD, 50% deposite and balanced before delivery.


3. Q: How can we test your quality
A: You are welcome to take samples for free, but the buyer afford the sample freight cost


Ortho-phthalaldehyde is a kind of pharmaceutical intermediate, which has been widely used in amine alkaloids, fluorometer histamine determination and medical inspection. The finished product is light yellow needle-like crystal, soluble in water, alcohol, ether and other organic solvents, without bad smell and stable in chemical properties. It was first used for endoscopic disinfection in 1994 and found that it has a broad-spectrum and efficient bactericidal effect. Subsequent studies have shown that o-phthalaldehyde has many advantages compared with glutaraldehyde. As a new type of high-efficiency chemical disinfectant for external use, in 1999, ortho-phthalaldehyde has passed the US FDA certification.



A. Sterilization mechanism


Different from the bactericidal mechanism of general disinfectants, the bactericidal activity of phthalaldehyde is based on its cross-linking effect with amino acids and proteins. Studies have shown that o-phthalaldehyde forms a strong cross-linking bond with the bacterial cell wall, creating a barrier that prevents these substances from damaging the cell wall/membrane structure. However, the sealing and anti-seepage effect of o-phthalaldehyde also causes the dysfunction of the exchange of substances inside and outside the bacteria, so that the normal physiological functions of the bacteria cannot be carried out, thereby promoting cell death.



On the other hand, the form of o-phthalaldehyde in water is different from that of glutaraldehyde. o-phthalaldehyde exists in the solution as a single molecule, so the free aldehyde groups can all play a role in disinfection, while the dialdehyde molecules are polymerized by aldehyde groups. The form exists, the acidity and alkalinity of the solution and other factors affect the degree of polymerization. The degree of polymerization is different, the number of exposed free aldehyde groups is different, and the number of free aldehyde groups determines its disinfection effect, so the bactericidal effect of o-phthalaldehyde is better than that of glutaraldehyde. Since o-phthalaldehyde is an aromatic aldehyde, it has good fat solubility and is more likely to penetrate the cell membrane of Mycobacterium tuberculosis and Gram-negative bacteria with more lipids, thereby acting on the target site inside the cell and causing rapid cell death. The killing effect of phthalaldehyde on Mycobacterium tuberculosis and Gram-negative bacteria is stronger than that of glutaraldehyde.



The spores are more resistant to the outside world than the bacterial propagules. This is because an outer structure containing a large amount of dipicolinic acid is formed in the later stage of spore maturation. Studies have found that ortho-phthalaldehyde mainly interacts with amino acids on the spore shell. This cross-linking forms a lethally strong coat that prevents spores from germinating, so phthalaldehyde kills Bacillus subtilis spores not by damaging DNA, but by inactivating spore germination. The effect of phthalaldehyde on the spore germination process is irreversible.






B. Application


O-phthalaldehyde has a strong killing effect on bacterial propagules, fungi, mycobacteria, viruses and spores. Experiments were carried out on the effect of phthalaldehyde in killing Bacillus subtilis black var. (C9372) spores, Candida albicans (ATOC10231), Escherichia coli (8099), Staphylococcus aureus (ATCC6538) and Pseudomonas aeruginosa PA01. In the carrier bactericidal test, 5000mg/L o-phthalaldehyde acts on Escherichia coli and Staphylococcus aureus for 3 minutes, and acts on Candida albicans for 5 minutes, so that the bacterial counts of the three species are reduced by more than 6log.



It has also been found that o-phthalaldehyde has a faster killing effect on mycobacteria, especially on glutaraldehyde-resistant Mycobacterium chelae. The concentration of 5000mg/L phthalaldehyde was treated for 10min and 20min respectively on the two glutaraldehyde-resistant strains of Mycobacterium Epping and Mycobacterium Hardidd. The killing effect of glutaraldehyde-resistant strains reached more than 6log. Formaldehyde can kill Mycobacterium tuberculosis for 5 minutes, and the killing effect on Mycobacterium tuberculosis can reach more than 5log, while glutaraldehyde of 15000mg/L needs to act 32rnin on these Mycobacterium chelae to achieve the same killing effect.


The U.S. Environmental Protection Agency has identified duck HBV as an indicator strain for human HBV inactivation. The duck HBV inactivation carrier experiment was carried out with o-phthalaldehyde, and the results showed that 3000mg/L o-phthalaldehyde could effectively kill duck hepatitis B virus at 20℃ for 5 minutes.



C. biological activity


O-phthalaldehyde belongs to the dialdehyde compound. Like glutaraldehyde, it mainly undergoes cross-linking reaction with amino acid groups, proteins and other components of microorganisms through aldehyde groups. Many experiments have shown that the crosslinking effect of o-phthalaldehyde is weaker than that of glutaraldehyde. This may be because o-phthalaldehyde can only react with the primary amino group (-NH2), so it can only react with lysine, arginine in the peptide chain and the amino acid at the end of the peptide chain. A hypothesis has been proposed to explain the weaker crosslinking effect of o-phthalaldehyde: first, the addition reaction of aromatic aldehydes (such as o-phthalaldehyde) is weaker than that of aliphatic aldehydes (such as glutaraldehyde). Second, the structure of ortho-phthalaldehyde contains a benzene ring, which makes the spatial structure of ortho-phthalaldehyde lack extensibility, so it is not easy to fully react with amino-containing substances by adjusting the spatial conformation. On the contrary, glutaraldehyde has greater extensibility and is easy to react with the amino group in the substance.



D. Stability and Corrosivity


O-phthalaldehyde has good stability in the pH range of 3-9, and its solution can be used continuously for 14 days. The American iCdxe company has developed a test paper to precisely monitor the concentration. Some data show that if the automatic endoscope cleaning procedure is used, it can be used repeatedly 82 times before reaching the minimum effective concentration, while glutaraldehyde is only used 40 times. Phthalaldehyde is not harmful to many metals, plastics and other substances.


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