You are here: Home / Products / Aldehyde Disinfectant / Ortho Phthalaldehyde Solution / High Level Disinfection 5L 0.55% OPA Sterilization Solution

High Level Disinfection 5L 0.55% OPA Sterilization Solution

SNOW-Brand 0.55% Ortho Pthalaldehyde Solution is a ready-to-use solution formulated with pharmacopoeia water. and are instrument-grade high level disinfectants commonly used in SA Health facilities to reprocess semi-critical reusable medical devices in accordance with manufacturer's instructions.
 
 
Availability:
Quantity:
  • Snow

SNOW-Brand 0.55% Ortho Pthalaldehyde Solution is a ready-to-use solution formulated with pharmacopoeia water. and are instrument-grade high level disinfectants commonly used in SA Health facilities to reprocess semi-critical reusable medical devices in accordance with manufacturer's instructions.


FEATURES & BENEFITS :
1. SNOW-brand 0.55% OPA solution  is a wide range of endoscopes and other heat-sensitive semi-critical medical devices Ideal for both automated and manual instrument reprocessing.
2. Faster turnaround time disinfectant with 5 minute contact time.
3. Long shelf-life up to 24 month
4. Test strip is escorted, easy to monitor the concentration.



OPA ortho-Phthalaldehyde Solution is a High-level Disinfectant for semi-critical medical devices and instruments.
Active Ingredient:  0.55% ortho-Phthalaldehyde .


OPA DISINFECTANT (2)


opa application 5L

Endoscopy and other hospital instrument sterilization.



Instructions for Use(IFU)

1. Clean the instrument & equipment and wiping dry.

2. For disinfection, soak the instrument & equipment with

cover for at least 5 minutes.

3. For sterilization, soak the instrument & equipment with

cover for at least 180 minutes.

4. Clean the instrument & equipment with distilled water




Guidance: 

How to Use ortho phthalaldehyde disinfectant OPA to Disinfect reusable medical devices(RMDs)?


· Wear Protective Visor, Clothes and gloves

· Clean the medical Device

· Check the OPA Solution concentration

· Disinfection Procedure

· Rinsing the Instruments

· Drying the Instruments

· Disposal of used OPA Solution


It is essential that precautions appropriate to the risk and mechanism of infection are followed  when reprocessing Reusable Medical Devices. 


Personal Protective Equipment is required to prevent OPA from contacting the skin and eyes. 

A  full-face visor should be worn throughout the disinfection process. 

Note: Contact lenses may  pose a special hazard and may absorb or concentrate irritants. In the event of chemical  exposure, begin eye irrigation immediately and remove contact lens as soon as practicable.  Lens should be removed at the first signs of eye redness or irritation. 


Gloves must be of appropriate length and should be made from a compatible material. 

Selection of gloves should be based on consideration of the task requirements 


OPA solution must be used in a well-ventilated area in closed containers with tight-fitting lids. If  adequate ventilation is not provided by the existing air conditioning system, use under local  exhaust hood, or under ductless fume hood or portable ventilation device. These should  contain filter media that absorbs OPA from the air. 


Sprays, mists and aerosols must not be generated during use of OPA. 


It is important that containers used in manual processes are filled and emptied in a manner  which does not put the worker at risk. Automated dispensing systems which can be  programmed to dispense the required amount of OPA are available commercially.


1.Q: How can you control your quality?
A: We inspect the goods from raw material to production and supervise the production. Our senior engineers test and inspect product randomly.


2.Q:What is your payment term?
A: Less than 10000 USD, T/T in advance. Over 10000 USD, 50% deposite and balanced before delivery.


3. Q: How can we test your quality?
A: Free sample is avaliable and You are welcome to take samples to check quality, and you afford sample freight only.


4. Q: How do you do high-level disinfection?

First, all of all, based on different job, choose the right disinfectant with proper ingredient is the key point.

After choose the right one, just follow disinfection procedure required, then done.


Ortho-phthalaldehyde is a kind of pharmaceutical intermediate, which has been widely used in amine alkaloids, fluorometer histamine determination and medical inspection. The finished product is light yellow needle-like crystal, soluble in water, alcohol, ether and other organic solvents, without bad smell and stable in chemical properties. It was first used for endoscopic disinfection in 1994 and found that it has a broad-spectrum and efficient bactericidal effect. Subsequent studies have shown that o-phthalaldehyde has many advantages compared with glutaraldehyde. As a new type of high-efficiency chemical disinfectant for external use, in 1999, ortho-phthalaldehyde has passed the US FDA certification.



Feature

1. Reliable sterilization effect, low corrosiveness to metals, little damage to other items, suitable for a variety of materials.

2. The volatile gas stimulates the respiratory tract, has a peculiar smell, is poor against mycobacteria, has a fixed effect on blood and tissues, and is more common in allergic and inflammatory reactions.

3. It has a fast killing speed and good effect on killing microorganisms, and has a good killing effect on mycobacteria resistant to glutaraldehyde and peracetic acid.

4. It is easy to use without activator.

5. The killing effect and stability of microorganisms are affected by pH value.


6. Low toxicity to humans, no irritating odor, no damage to items, suitable for a variety of materials.


Is Opa a high level disinfectant?


Yes, the OPA disinfectand is do a high-level disinfectant. Following is a scientific view study on it.



A. Sterilization mechanism


Different from the bactericidal mechanism of general disinfectants, the bactericidal activity of phthalaldehyde is based on its cross-linking effect with amino acids and proteins. Studies have shown that o-phthalaldehyde forms a strong cross-linking bond with the bacterial cell wall, creating a barrier that prevents these substances from damaging the cell wall/membrane structure. However, the sealing and anti-seepage effect of o-phthalaldehyde also causes the dysfunction of the exchange of substances inside and outside the bacteria, so that the normal physiological functions of the bacteria cannot be carried out, thereby promoting cell death.



On the other hand, the form of o-phthalaldehyde in water is different from that of glutaraldehyde. o-phthalaldehyde exists in the solution as a single molecule, so the free aldehyde groups can all play a role in disinfection, while the dialdehyde molecules are polymerized by aldehyde groups. The form exists, the acidity and alkalinity of the solution and other factors affect the degree of polymerization. The degree of polymerization is different, the number of exposed free aldehyde groups is different, and the number of free aldehyde groups determines its disinfection effect, so the bactericidal effect of o-phthalaldehyde is better than that of glutaraldehyde. Since o-phthalaldehyde is an aromatic aldehyde, it has good fat solubility and is more likely to penetrate the cell membrane of Mycobacterium tuberculosis and Gram-negative bacteria with more lipids, thereby acting on the target site inside the cell and causing rapid cell death. The killing effect of phthalaldehyde on Mycobacterium tuberculosis and Gram-negative bacteria is stronger than that of glutaraldehyde.



The spores are more resistant to the outside world than the bacterial propagules. This is because an outer structure containing a large amount of dipicolinic acid is formed in the later stage of spore maturation. Studies have found that ortho-phthalaldehyde mainly interacts with amino acids on the spore shell. This cross-linking forms a lethally strong coat that prevents spores from germinating, so phthalaldehyde kills Bacillus subtilis spores not by damaging DNA, but by inactivating spore germination. The effect of phthalaldehyde on the spore germination process is irreversible.


B. Application


O-phthalaldehyde has a strong killing effect on bacterial propagules, fungi, mycobacteria, viruses and spores. Experiments were carried out on the effect of phthalaldehyde in killing Bacillus subtilis black var. (C9372) spores, Candida albicans (ATOC10231), Escherichia coli (8099), Staphylococcus aureus (ATCC6538) and Pseudomonas aeruginosa PA01. In the carrier bactericidal test, 5000mg/L o-phthalaldehyde acts on Escherichia coli and Staphylococcus aureus for 3 minutes, and acts on Candida albicans for 5 minutes, so that the bacterial counts of the three species are reduced by more than 6log.



It has also been found that o-phthalaldehyde has a faster killing effect on mycobacteria, especially on glutaraldehyde-resistant Mycobacterium chelae. The concentration of 5000mg/L phthalaldehyde was treated for 10min and 20min respectively on the two glutaraldehyde-resistant strains of Mycobacterium Epping and Mycobacterium Hardidd. The killing effect of glutaraldehyde-resistant strains reached more than 6log. Formaldehyde can kill Mycobacterium tuberculosis for 5 minutes, and the killing effect on Mycobacterium tuberculosis can reach more than 5log, while glutaraldehyde of 15000mg/L needs to act 32rnin on these Mycobacterium chelae to achieve the same killing effect.


The U.S. Environmental Protection Agency has identified duck HBV as an indicator strain for human HBV inactivation. The duck HBV inactivation carrier experiment was carried out with o-phthalaldehyde, and the results showed that 3000mg/L o-phthalaldehyde could effectively kill duck hepatitis B virus at 20℃ for 5 minutes.



C. biological activity


O-phthalaldehyde belongs to the dialdehyde compound. Like glutaraldehyde, it mainly undergoes cross-linking reaction with amino acid groups, proteins and other components of microorganisms through aldehyde groups. Many experiments have shown that the crosslinking effect of o-phthalaldehyde is weaker than that of glutaraldehyde. This may be because o-phthalaldehyde can only react with the primary amino group (-NH2), so it can only react with lysine, arginine in the peptide chain and the amino acid at the end of the peptide chain. A hypothesis has been proposed to explain the weaker crosslinking effect of o-phthalaldehyde: first, the addition reaction of aromatic aldehydes (such as o-phthalaldehyde) is weaker than that of aliphatic aldehydes (such as glutaraldehyde). Second, the structure of ortho-phthalaldehyde contains a benzene ring, which makes the spatial structure of ortho-phthalaldehyde lack extensibility, so it is not easy to fully react with amino-containing substances by adjusting the spatial conformation. On the contrary, glutaraldehyde has greater extensibility and is easy to react with the amino group in the substance.



D. Stability and Corrosivity


O-phthalaldehyde has good stability in the pH range of 3-9, and its solution can be used continuously for 14 days. The American iCdxe company has developed a test paper to precisely monitor the concentration. Some data show that if the automatic endoscope cleaning procedure is used, it can be used repeatedly 82 times before reaching the minimum effective concentration, while glutaraldehyde is only used 40 times. Phthalaldehyde is not harmful to many metals, plastics and other substances.



Is glutaraldehyde the same as OPA?


Of course not. Glutaraldehyde is one of refered to. And the glutaraldehyde-contained disinfectant was named by Plus in johnson-johnson company. OPA is an ortho-phthalaldehyde disinfectant containing ortho-phthalaldehyde and glutaraldehyde contains glutaraldehyde only. Active ingredient differs. As well, OPA is a trade-mark of johnson-johnson.



Can OPA go down the drain?


Please always respect local regulation & rule to dispose since it’s disinfectant may hurt environment.



How long does it take glutaraldehyde to sterilize?


As a disinfection procedure to take glutaraldehyde, it’s 45~60 minutes.


As a sterilization procedure to take glutraldehyde, it’s 600 minutes recommended



What is OPA cleaner?


Generally, it’s something like enzyme-contained detergent, alkine detergent, acid detergent, which can remove gross filth and heavy soils before disinfection precedure. Pre-cleanning is a compulsory action before disinfection



What is high level disinfection?


High-level disinfection refers to killing all bacterial propagules including mycobacteria, viruses, fungi and their spores and most bacterial spores. Commonly used methods to achieve high-level disinfection include the use of chlorine-containing preparations, chlorine dioxide,glutaraldehyde, o-phthalaldehyde, peracetic acid, hydrogen peroxide, ozone, iodine tincture, acidic oxidized electrolyzed water (AEOW), etc., and chemical agents that can achieve sterilization effects. Disinfectant is a method of disinfecting with appropriate concentration and effective action time under specified conditions.



What is the difference between OPA and glutaraldehyde?


Compared with glutaraldehyde, the advantages of ortho-phthalaldehyde are as follows:


1. Quick turn-over


Ready to use, no activation, mixing or dilution required.


Save 50%-70% time than glutaraldehyde.


Shorten the cycle of endoscope disinfection and improve the turnover rate.


2. More efficient


Broad-spectrum bactericidal efficacy.


Kills 2% glutaraldehyde-tolerant mycobacteria in 5 minutes.


3. More durable


At high loads, phthalaldehyde can last for an average of 140 disinfection cycles, while glutaraldehyde can last for 90 disinfection cycles.


4. Safer


No ventilation is required.


No OSHA permissible limit requirements are required.


No inhalation toxicity and mucosal toxicity.


Widely used so far no cases of acute toxicity, teratogenicity and mutagenesis have been found.


Unique coloring tips.


5. Gentle: much more kind to devices


Does not contain any surfactants.


near neutral pH.


Broad material compatibility.



What are the chemicals used in high-level disinfection?


Commonly used methods to achieve high-level disinfection include the use of chlorine-containing preparations, chlorine dioxide,glutaraldehyde, o-phthalaldehyde, peracetic acid, hydrogen peroxide, ozone, iodine tincture, acidic oxidized electrolyzed water (AEOW), etc.,




Previous: 
Next: 
Wuhan Snow Medical Disinfectant Co., Ltd is a leading disinfectant factory since 1999.

Quick Links

Product Category

Contact Us

Tel: +86-15827109570
Phone: +86-15827109570
Whatsapp: +86-15827109570
Add: 18, Yinhu Science & Technology Industrial Park,Dongxihu District, Wuhan, Hubei, China 430040
Copyright © 2023 Wuhan Snow Medical Disinfectant Co., Ltd. Supported by Leadong.  Sitemap. Privacy Policy